Source Listing and Validating the Marik Protocol Treatment for Sepsis
Researched and Created March 2020

—Journal Chest
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study
Paul E.MarikMD, FCCPaVikramjitKhangooraMDaRacquelRiveraPharmDbMichael H.HooperMDaJohnCatravasPhD, FCCPcd
CHEST Volume 151, Issue 6, June 2017, Pages 1229-1238
https://www.sciencedirect.com/science/article/abs/pii/S0012369216625643

–Critical Care Medicine Journal
HYDROCORTISONE/ASCORBIC ACID/THIAMINE USE ASSOCIATED WITH LOWER MORTALITY IN PEDIATRIC SEPTIC SHOCK
Wald, Eric1; Sanchez-Pinto, L. Nelson1; Smith, Craig1; Moran, Thomas1; Badke, Colleen1; Barhight, Matthew1; Malakooti, Marcelo
Critical Care Medicine: January 2020 – Volume 48 – Issue 1 – p 13
doi: 10.1097/01.ccm.0000618600.13062.e9
https://journals.lww.com/ccmjournal/Fulltext/2020/01001/25__HYDROCORTISONE_ASCORBIC_ACID_THIAMINE_USE.28.aspx

–Series of Video Interviews of Paul Marik, MD and of Sepsis treatment
https://www.youtube.com/results?search_query=marik+protocol+for+sepsis

–Slides from Presentation by Paul E. Marik, MD
2020 Australian Critical Care Review Conference
2018 Critical Care Canada Conference
https://criticalcarecanada.com/presentations/2018/hydrocortisone_vitamin_c_and_thiamine_for_septic_shock.pdf

–International Journal of Vitamin and Nutrition Research
Clinical Trial
Int J Vitam Nutr Res, 64 (3), 212-9, 1994
The Clinical Effects of Vitamin C Supplementation in Elderly Hospitalised Patients With Acute Respiratory Infections
C Hunt 1, N K Chakravorty, G Annan, N Habibzadeh, C J Schorah
PMID: 7814237
https://pubmed.ncbi.nlm.nih.gov/7814237-the-clinical-effects-of-vitamin-c-supplementation-in-elderly-hospitalised-patients-with-acute-respiratory-infections/

–Journal of Clinical Medicine
J Clin Med, 8 (4), 2019 Apr 9
Vitamin C, Hydrocortisone, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Analysis of Real-World Application
Jane J Litwak 1, Nam Cho 2 3, H Bryant Nguyen 4 5, Kayvan Moussavi 6, Thomas Bushell 7 8
PMID: 30970560, PMCID: PMC6518003, DOI: 10.3390/jcm8040478
https://pubmed.ncbi.nlm.nih.gov/30970560-vitamin-c-hydrocortisone-and-thiamine-for-the-treatment-of-severe-sepsis-and-septic-shock-a-retrospective-analysis-of-real-world-application/

–Annals of Intensive Care
Effects of different ascorbic acid doses on the mortality of critically ill patients: a meta-analysis
Wang, Y., Lin, H., Lin, B. et al. Effects of different ascorbic acid doses on the mortality of critically ill patients: a meta-analysis. Ann. Intensive Care 9, 58 (2019). https://doi.org/10.1186/s13613-019-0532-9
Received16 January 2019, Accepted13 May 2019, Published20 May 2019, DOIhttps://doi.org/10.1186/s13613-019-0532-9
https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-019-0532-9

–Journal Trials
Trials, 20 (1), 420, 2019 Jul 11
Combination Therapy of Vitamin C and Thiamine for Septic Shock in a Multicentre, Double-Blind, Randomized, Controlled Study (ATESS): Study Protocol for a Randomized Controlled Trial
Sung Yeon Hwang 1, Jong Eun Park 1, Ik Joon Jo 1, Seonwoo Kim 2, Sung Phil Chung 3, Taeyoung Kong 3, Jonghwan Shin 4, Hui Jai Lee 5, Kyoung Min You 5, You Hwan Jo 6, Doyun Kim 6, Gil Joon Suh 7, Taegyun Kim 7, Won Young Kim 8, Youn-Jung Kim 8, Seung Mok Ryoo 8, Sung-Hyuk Choi 9, Tae Gun Shin 10, Korean Shock Society (KoSS) Investigators
PMID: 31296251, PMCID: PMC6624963, DOI: 10.1186/s13063-019-3542-x
https://pubmed.ncbi.nlm.nih.gov/31296251-combination-therapy-of-vitamin-c-and-thiamine-for-septic-shock-in-a-multicentre-double-blind-randomized-controlled-study-atess-study-protocol-for-a-randomized-controlled-trial/

–Critical Care Journal
Vitamin C administration in the critically ill: a summary of recent meta-analyses
Published: 30 July 2019
Anitra C. Carr , Critical Care volume 23, Article number: 265 (2019)
https://ccforum.biomedcentral.com/articles/10.1186/s13054-019-2538-y

–Journal Nutrients
Nutrients, 11 (9), 2019 Aug 23
Administration of Intravenous Ascorbic Acid-Practical Considerations for Clinicians
Scott E Walker 1 2, John Iazzetta 3, Shirley Law 3, Salmaan Kanji 4, Brigitte Bolduc 5, François Lamontagne 6, Neill K J Adhikari 7
PMID: 31450771, PMCID: PMC6769642, DOI: 10.3390/nu11091994
https://pubmed.ncbi.nlm.nih.gov/31450771-administration-of-intravenous-ascorbic-acid-practical-considerations-for-clinicians/

–Journal of Clinical Medicine
J Clin Med, 8 (1) 2019 Jan 16
Early Vitamin C and Thiamine Administration to Patients With Septic Shock in Emergency Departments: Propensity Score-Based Analysis of a Before-and-After Cohort Study
Tae Gun Shin 1, Youn-Jung Kim 2, Seung Mok Ryoo 3, Sung Yeon Hwang 4, Ik Joon Jo 5, Sung Phil Chung 6, Sung-Hyuk Choi 7, Gil Joon Suh 8, Won Young Kim 9
PMID: 30654592, PMCID: PMC6352246, DOI: 10.3390/jcm8010102
https://pubmed.ncbi.nlm.nih.gov/30654592-early-vitamin-c-and-thiamine-administration-to-patients-with-septic-shock-in-emergency-departments-propensity-score-based-analysis-of-a-before-and-after-cohort-study/

–Indian Journal of Anaesthhesia
Indian J Anaesth, 62 (12), 934-939 Dec 2018
Hydrocortisone, Vitamin C and Thiamine for the Treatment of Sepsis and Septic Shock Following Cardiac Surgery
Mahesh Balakrishnan 1, Hemang Gandhi 1, Komal Shah 1, Himani Pandya 1, Ramesh Patel 1, Sunny Keshwani 1, Nikhil Yadav 1
PMID: 30636793, PMCID: PMC6299773, DOI: 10.4103/ija.IJA_361_18
https://pubmed.ncbi.nlm.nih.gov/30636793-hydrocortisone-vitamin-c-and-thiamine-for-the-treatment-of-sepsis-and-septic-shock-following-cardiac-surgery/

–Journal Nutrients
Nutrients, 10 (11) 2018 Nov 14
Hydrocortisone, Ascorbic Acid and Thiamine (HAT Therapy) for the Treatment of Sepsis. Focus on Ascorbic Acid
Paul E Marik 1
PMID: 30441816, PMCID: PMC6265973, DOI: 10.3390/nu10111762
https://pubmed.ncbi.nlm.nih.gov/30441816-hydrocortisone-ascorbic-acid-and-thiamine-hat-therapy-for-the-treatment-of-sepsis-focus-on-ascorbic-acid/

— Journal of Critical Care
Crit Care, 22 (1), 283 2018 Oct 29
Ascorbic Acid, Corticosteroids, and Thiamine in Sepsis: A Review of the Biologic Rationale and the Present State of Clinical Evaluation
Ari Moskowitz 1, Lars W Andersen 2 3 4, David T Huang 5 6, Katherine M Berg 1, Anne V Grossestreuer 2, Paul E Marik 7, Robert L Sherwin 8, Peter C Hou 9, Lance B Becker 10 11, Michael N Cocchi 2 12, Pratik Doshi 13, Jonathan Gong 14, Ayan Sen 15, Michael W Donnino 16 17 18
PMID: 30373647, PMCID: PMC6206928, DOI: 10.1186/s13054-018-2217-4
https://pubmed.ncbi.nlm.nih.gov/30373647-ascorbic-acid-corticosteroids-and-thiamine-in-sepsis-a-review-of-the-biologic-rationale-and-the-present-state-of-clinical-evaluation/

–Journal of Manipulative and Physiological Therapeutics
J Manipulative Physiol Ther, 22 (8), 530-3 Oct 1999
The Effectiveness of Vitamin C in Preventing and Relieving the Symptoms of Virus-Induced Respiratory Infections
H C Gorton, K Jarvis
PMID: 10543583, DOI: 10.1016/s0161-4754(99)70005-9
https://pubmed.ncbi.nlm.nih.gov/10543583-the-effectiveness-of-vitamin-c-in-preventing-and-relieving-the-symptoms-of-virus-induced-respiratory-infections/?from_single_result=%22Journal+of+manipulative+and+physiological+therapeutics%22%5BJour%5D+AND+530%5Bpage%5D+AND+1999%2F10%5Bpdat%5D
Vitamin C in megadoses administered before or after the appearance of cold and flu symptoms relieved and prevented the symptoms in the test population compared with the control group.

–Journal Antimicrobial Chemotherapy
Vitamin C and SARS coronavirus
Journal of Antimicrobial Chemotherapy, DOI: 10.1093/jac/dkch002, Vitamin C and SARS Coronavirus, Page 1049 (PDF)
2003

–The Clinical Experiences of Frederick R. Klenner, MD
https://www.seanet.com/~alexs/ascorbate/198x/smith-lh-clinical_guide_1988.htm
Review of the history of cases of influenza, encephalitis, and measles that were easily cured with vitamin C injections and oral doses.